We identified with high confidence 164 exosome-derived proteins common for all four cell lines that were annotated in ExoCarta and Vesiclepedia databases.

A multitude of EV‐associated miRs have been registered in open‐access databases such as ExoCarta and Vesiclepedia. To date, five studies have reported a total of 39 differentially expressed plasma‐ 5 or serum‐isolated 15 , 29 , 36 , 40 EV‐associated miRs in AD dementia …

With In addition, we have initiated an ongoing process of extractions of gene product annotations associated with these terms from Vesiclepedia and ExoCarta, conversion of the extracted annotations to Gene Association File (GAF) format for batch submission to GO, and curation of the submitted annotations by the GO Consortium. Gene product annotations extracted from ExoCarta and Vesiclepedia. At the time of writing this manuscript, 18,695 coding (mRNA and protein) and 963 non-coding (ncRNAs) gene products (including isoforms) were annotated with the GO terms: ‘extracellular vesicle’, ‘extracellular exosome’, ‘apoptotic body’ and ‘microvesicle’ identified in different species (Table 2) from ExoCarta EXOCARTA was the first of these databases to be launch and includes data only from exosomes (http://www.exocarta.org/) [148,149,150,151]. Vesiclepedia was launched later and, now, it gathers information from all classes of extracellular vesicles among them exosomes, microparticles and microvesicles ( http://microvesicles.org/ ) [ 152 , 153 ]. Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment.

Exocarta vesiclepedia

The new version of ExoCarta database has more than 2-fold data compared to the last release in 2012 and has new additional features including the annotation of International Society for Extracellular Vesicles (ISEV) standards and dynamic protein–protein interaction networks. Compared to the exosomal database ExoCarta , Vesiclepedia (http://www.microvesicles.org) is a compendium that catalogues proteins, RNAs, lipids and metabolites that are identified in all classes of EVs . Vesiclepedia was built using ZOPE, an open source content management system, while Python a portable, interpreted, object oriented programming language was utilised to connect the web interface with the MySQL database. As sources of gene product annotations in the exRNA context, ExoCarta and Vesiclepedia are online databases that catalogue proteins, RNAs and lipids identified specifically in exosomes and other extracellular vesicle types, respectively. Recently, ExoCarta was updated with ISEV minimal experimental requirements feature for definition of extracellular vesicles. Extracellular vesicles (EVs) are membranous vesicles that are released by both prokaryotic and eukaryotic cells into the extracellular microenvironment.

Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, Exosomes (30-140 nm) and larger microvesicles [MVs] (100-1000 nm) are subcategories of extracellular vesicles that are released into the circulation. Exosomes contain peptides and several nucleic acids (microRNA [miRNA], messenger RNA [mRNA], mitochondrial DNA [mtDNA]) and are involved in intercellular/tissue exchange of their contents.

Furthermore, we constructed a list of the top 100 proteins identified in three online EV databases (EVpedia, ExoCarta and VesiclePedia [87] [88] [89], and when performing a multi-group comparison

Consortium login. The exRNA Atlas is developed and maintained by the Data Management and Resource Repository (DMRR). It includes exRNA profiles derived from various biofluids and conditions and currently stores data profiled from small RNA sequencing assays.

2018-01-04

An overall comparison of EVpedia with Exocarta and Vesiclepedia is shown in Tables I and II. These three web‐based repositories contain proteomic, transcriptomic and lipidomic studies of non‐mammalian eukaryotic and mammalian EVs. However, only EVpedia provides additional proteomic and lipidomic studies on prokaryotic EVs (Table I). ExoCarta collects information regarding the cargoes of exosomes, whereas Vesiclepedia includes microvesicles and apoptotic bodies in their consortium [101,102]. As of 2019, Vesiclepedia has compiled over 1200 studies cataloging the presence of about 32,000 unique proteins, 17,000 unique mRNAs, 2400 unique miRNAs, and more than 600 lipids and Exosomes (30-140 nm) and larger microvesicles [MVs] (100-1000 nm) are subcategories of extracellular vesicles that are released into the circulation. Exosomes contain peptides and several nucleic acids (microRNA [miRNA], messenger RNA [mRNA], mitochondrial DNA [mtDNA]) and are involved in intercellular/tissue exchange of their contents. three online databases (ExoCarta, Vesiclepedia and EVpedia). For each database, the pro-teins found in exosomes were collected and a list of proteins/corresponding genes present was produced for each bioﬂuid. The ﬁnal bioﬂuid proteome lists also include proteins Over 200,000 vesicular proteins, mRNAs, miRNAs, and lipids identified in non‐mammalian eukaryotic and mammalian EVs, have been compiled in the Exocarta database (16, 17), which was recently updated into Vesiclepedia (http://www.microvesicles.org; 18).

As exosomes contain RNA, proteins and lipids, there is a significant interest in characterizing the molecular cargo of exosomes. Data deposited to ExoCarta can also be accessed through Vesiclepedia; however, only high quality exosomal datasets deposited to Vesiclepedia can be accessed through ExoCarta. With the launch of Vesiclepedia, we expect to have an organised data deposition mechanism. EVpedia provides high-throughput datasets of vesicular components (proteins, mRNAs, miRNAs, and lipids) present on prokaryotic, non-mammalian eukaryotic, and mammalian extracellular vesicles. Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment.
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With the launch of Vesiclepedia, we expect to have an organised data deposition mechanism. ExoCarta update published in J Molecular Biology ExoCarta: A web-based compendium of exosomal cargo!!! 19/12/2012. Currently, Vesiclepedia comprises 35,264 protein, 18,718 mRNA, 1,772 miRNA and 342 lipid entries encompassed from 341 independent … List of top 100 proteins that are often identified in EVs. DOWNLOAD HERE List of top 100 proteins that are often identified in exosomes [Download here ].

Finally, by appending all databases, it was found that 67/72 proteins were secreted. Further support for the role of exosomes (and possibly MVs) in mediating the systemic benefits of exercise comes from the fact that the majority of the previously reported myokines/exerkines are found in extracellular vesicles databases (Vesiclepedia and ExoCarta).
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Data deposited to ExoCarta can also be accessed through Vesiclepedia; however, only high quality exosomal datasets deposited to Vesiclepedia can be accessed through ExoCarta. With the launch of Vesiclepedia, we expect to have an organised data deposition mechanism.

Extracellular. vesicles are spherical bilayered proteolipids with a mean diameter of 20 1,000 nm, which are known to.

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Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation. Abstract: Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery,

2020-06-23 · When we compared our results to the current published public EV datasets, Vesiclepedia and Exocarta.